Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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Bondareff, W. et al. (1994) Immunohistochemical staging of neurofibrillary degeneration in Alzheimer's disease. Available at Journal of Neuropathology & Experimental Neurology
Bondareff, W. et al. (1994) Presence of axonal paired helical filament tau in Alzheimer's disease: submicroscopic localization. Available at Journal of Neuroscience Research
Harrington, C.R., et al. (1994) Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients. Available at Lancet
Harrington, C.R., et al. (1994) Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease. Available at American Journal of Pathology
Harrington, C.R., et al. (1994) Senile dementia of Lewy body type and Alzheimer type are biochemically distinct in terms of paired helical filaments and hyperphosphorylated tau protein. Available at Dementia