Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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Bondareff, W. et al. (1995) Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. Available at Journal of Neuropathology & Experimental Neurology
Lai R.Y.K., et al. (1995) Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer's disease. Available at Neurobiology of Aging
Mena, R. et al. (1995) Monitoring pathological assembly of tau and b-amyloid proteins in Alzheimer's disease. Available at Acta Neuropathologica
Wischik, C.M., et al. (1995) Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease. Available at Neurobiology of Aging