Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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Gertz, H-J. et al. (1996) The relationship between clinical dementia and neuropathological staging (Braak) in a very elderly community sample. Available at Eur Arch Psychiatry Clin Neurosci
Mena, R. et al. (1996) Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. Available at Acta Neuropathologica
Wischik, C.M., et al. (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Available at Proceedings of the National Academy of Sciences of the United States of America