Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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García-Sierra, F. et al. (2000) The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old. Available at Acta Neuropathologica
Mukaetova-Ladinska, E.B. et al. (2000) Staging of cytoskeletal and b-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease. Available at American Journal of Pathology
Wischik, C.M., et al. (2000) The molecular basis of tau protein pathology in Alzheimer's disease and related neurodegenerative dementias. In Neurobiology of Alzheimer’s Disease (Eds. D Dawbarn, SJ Allen) Oxford University Press, Oxford, 103-206.