Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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Al-Hilaly, Y.K., et al. (2017) Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking. Available at: Journal of Molecular Biology
Miguel Angel Ontiveros-Torres, et al. (2017) Carboxy-Terminus Tau Protein Hyperphosphorylation is Associated with Extracellular Deposits of Amyloid-β Fibrillary in a Triple-Transgenic Model of Alzheimer’s Disease. Available at Journal of Neurological Disorders
Schwab, K, et al. (2017) LMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE. Available at: Alzheimer's and Dementia.
Shiells, H, et al. (2017) The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks. Available at: Medical Research Archives.
Šimić, G, et al. (2017) Monoaminergic Neuropathology in Alzheimer's disease. Available at: Progress in Neurobiology.