Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer’s, frontotemporal dementia and other neurodegenerative diseases. Prof. Wischik discovered that the neurofibrillary tangles seen in Alzheimer’s disease are made of sub-units of the tau protein and he and his team have published extensively in the field.
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Al-Hilaly, Y.K. et al. (2020) Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain. Available at FEBS Letters
Arastoo, M, et al, (2020) Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics. Available at: International Journal of Molecular Sciences
Cranston, A.L., et al (2020) Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration. Available at: Brain Communications.
Hernandes-Alejandro, M., et al, (2020) Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease. Available at: Journal of Alzheimer's Disease
Lemke, N., et al (2020) Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. Available at: Journal of Biological Chemistry