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Neurodegenerative disorders

Identifying the common pathological features

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A cascade of aggregation

Many neurodegenerative disorders, such as Alzheimer’s disease, share common pathological features including the misfolding and aggregation of tau proteins. Normally, cellular mechanisms degrade these proteins into their components for recycling. 

The only tau-targeting
therapy awaiting MHRA decision

We are researching treatments that have the potential to modify the disease course in conditions that involve protein aggregation pathology. We are investigating a class of drugs known as Tau Aggregation Inhibitors (TAIs), which interfere with the abnormal aggregation process and formation of tau tangles. Tau aggregates are thought to be particularly toxic to nerve cells. To our knowledge, no other company in the world has a TAI pending approval for widespread use by the Medicines and Healthcare products Regulatory Agency (MHRA).

Our TAIs have the potential to target proteins in the following neurodegenerative conditions:
  • Alzheimer’s disease
  • Behavioural variant frontotemporal dementia or bvFTD
  • Chronic traumatic encephalopathy
  • Progressive supranuclear palsy
  • Cortico-basal degeneration
  • Parkinson’s disease
  • Huntington’s disease
  • Amyotrophic lateral sclerosis
$1.3 trillion

Global cost of dementia (USD)*

*Latest available statistics from the World Health Organization

Further reading

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Tau and tau pathology

Healthy tau protein is critical for stabilising cell structure in the brain, but can disrupt neuronal function if it misfolds.
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Neurofilament Light Chain (NfL)

This biomarker for damaged brain cells can be a powerful tool for measuring and predicting disease progression.
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Tau inhibition

Our product, HMTM, belongs to a class of drugs known as Tau Aggregation Inhibitors (TAIs). These work by preventing and dissolving tau aggregates, to preserve the normal tau function essential for a healthy brain.