Clinical trials

Advancing our understanding through rigorous scientific trials

Doctor or nurse caregiver with senior couple at home or nursing home

Our clinical trial history
spanning the last 20 years

Here you’ll find a comprehensive overview and links to detailed information on our past studies, including their objectives, methods and results. These trials represent milestone, sometimes breakthrough, steps in our understanding of tau aggregation inhibitors and their potential in treating neurodegenerative diseases.

Explore this timeline for insights into the progression and depth of our scientific efforts.

  • 1988

  • 1996

  • 2002

  • 2004

  • 2012

  • 2016

  • 2017

  • 2020

  • 2022

  • 2023

  • 2024

  • 1988

    Claude Wischik discovers structure of tau tangles.

  • 1996

    Wischik discovers tau tangles can be dissolved by methylthionimium class molecules. He and his team publish first report on Tau Aggregation Inhibitors (TAI).

  • 2002

    TauRx founded in Singapore.

  • 2004-2008
    • First Phase II trial of Tau Aggregation Inhibitor (TAI)
    • Phase II results released (2008)

     

  • 2012-2016

    First phase III trials in mild-moderate AD and frontotemporal dementia conducted.

  • 2016

    First Phase III full study results published in The Lancet. Topline results presented at Clinical Trials on Alzheimer's Disease (CTAD) Conference.

  • 2017-2018

    Pivotal "Lucidity" Phase III monotherapy trial begins in North America.

  • 2020

    Preclinical studies show Tau Aggregation Inhibitor (TAI) enhances neuron communication.

  • 2022

    Lucidity Phase III topline data presented at CTAD, the only oral anti-tau therapy in late-stage development

  • 2023

    Lucidity trial completes open-label phase.

  • 2024

    Marketing Authorisation Application for TauRx's First product - a tablet to treat MCI due to Alzheimer's Disease - submitted to the UK's Medicines and Healthcare products Regulatory Agency (MHRA).

1988
1996
2002
2004-2008
2012-2016
2016
2017-2018
2020
2022
2023
2024

In collaboration with neurologists and clinical research centres in North America and Europe, TauRx's pivotal Phase III clinical trial, named LUCIDITY, aimed to prove our investigational drug works, following earlier tests that showed it has measurable effects even in small amounts. The trial studied the effect of the drug on participants with mild cognitive impairment due to Alzheimer’s and mild to moderate Alzheimer’s.

The trial applied commonly-used clinical assessments to check cognitive skills and daily functioning, along with brain scans and blood tests. These helped us measure how well our drug might slow down Alzheimer’s disease (AD), and included an open-label phase during which all participants received the active drug. Patients completing the full trial were eligible for continued use of the drug under an Expanded Access Programme.

TauRx also completed its Phase III trial related to the rare neurodegenerative disorder, behavioural variant frontotemporal dementia (bvFTD).